GIST Support Wiki


Gleevec and other drugs may cause diarrhea (urgent loose bowel movements) at times (gleevec trots).

Suggestions include:

  • Poppy juice dissolved in alcohol. Denatured tincture of opium (DTO) 10-12 drops in water every four hours
  • Imodium from Janssen
  • Take one Imodium (Loperamide Hydrochloride) 2mg along with 400 mg Gleevec at night. That slows down your bowels enough that food can be absorbed and prevent weightloss.
  • Diarrhoe Relief tablets with Kaolin 400 mg and Calcium Carbonate 75 mg or any comparable product.
  • Bioflorin Giuliani capsules containing 75 million enterococci SF 68 viv. per capsule.
  • Acidophilus is a probiotic of beneficial intestinal bacteria which works to put you back in balance.
  • Chamomile flowers and concentrated Chamomile in alcohol: Recipe: 2 full spoons of dried Chamomile flowers + 200 CC of boiling water. Filter.
  • Change calcium supplement. taking cal/mag/zinc tablets, the magnesium in them with the Gleevec was too much and made the diarrhea worse. Take calcium with Vit. D added and it works well.
  • Cheese: No 'cheesy' jokes today but cheese really does help.
  • Codeine: After my surgery, I was prescribed codeine for the diarrhea.
  • Interestingly enough, the same foods that are suggested for constipation often work for diarrhea. The reason for this is that fiber in the diet helps absorb water and helps the stool move through the gut at an appropriate speed. You might try starting with something like oatmeal or some whole wheat crackers.
  • Yogurts made with live cultures will help repopulate the gut with beneficial bacteria and often will lessen diarrhea. Read the label to see if it is made with live culture.
  • Konsyl natural fiber supplement. It worked for me. The diarrhea was so bad that I rubbed myself raw wiping and couldn't sleep because of the burning.
  • Lotomil
  • I was advised to eat short-grain-brown-rice 2x a day. (any old rice won't do). It really helped.
  • Mylanta instead of Prilosec: For one full year I had a problem with diarrhea EVERY day -caused by Gleevec...... (I take 400 mg Gleevec.) Recently, I got off Prilosec and now use Mylanta for an acid reducer. The results have been astonishing ! - The Mylanta has COMPLETELY taken away the diarrhea. It was like turning off a switch. From the day I started with the Mylanta, I had INSTANT relief from the diarrhea. The Mylanta - "Ultimate Strength" is working well for my acid problems too!
  • Macaroons, according to!

  • Align for diarrhea. It's a probiotic in capsule form that is advertised to "provide ongoing protection from episodic diarrhea and constipation".
  • My Onc suggested Yakult - a probiotic drink with a specific probiotic called "Kasei sherota" - not sure if I spelled it right. It helped me out and my poo was solid by the next day. I try to drink one daily now to keep the diarrhea away and it has helped do far.

Diarrhea smoothie recipe from the Block Integrative Cancer Center in Evanston, IL

  • 1 scoop of Essential Whey protein powder (Proserum whey best - we like Pro-optimal whey from
  • 2-3 teaspoons L-glutamine powder
  • 1 capsule (opened) Florastor probiotic (Saccharomyces boulardii - can get from pharmacist - start with half capsule as it may cause flatulence)
  • 1 tablespoon carob powder
  • 1 tablespoon Kuzu root powder or arrowroot powder (health food store)
  • 1 banana
  • 1-2 tablespoons almond butter (or all-natural peanut butter)
  • 1/2 cup applesauce
  • 1 cup coconut kefir, coconut milk or rice milk
  • 1 tsp agave (optional)
  • 1/2 to 1 tablespoon MCT oil (medium chain triglyceride oil helpful for people with fat-malabsorption and enzymatic insufficiency as well as adding additional fats to their diet to gain weight)

Sore bottom from diarrhea The best stuff I have found for raw bottoms from constant diarrhea is 'Balneol' by Solvay Pharmaceuticals, Inc. It is a soothing perianal cleansing lotion that really works great.